Nucleosides and nucleotides. 127. A novel and convenient post-synthetic modification method for the synthesis of oligodeoxyribonucleotides carrying amino linkers at the 5-position of 2′-deoxyuridine
| Autor: | Mitsugu Kiyokawa, Noriaki Minakawa, Noriyasu Haginoya, Akira Ono, Akira Matsuda |
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| Rok vydání: | 1994 |
| Předmět: |
chemistry.chemical_classification
Oligonucleotide medicine.drug_class Organic Chemistry Clinical Biochemistry Intercalation (chemistry) Pharmaceutical Science Carboxamide Biochemistry Combinatorial chemistry Deoxyuridine Quinone Deoxyribonucleotide chemistry.chemical_compound chemistry Drug Discovery medicine Molecular Medicine Nucleotide Molecular Biology Nucleoside |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 4:361-366 |
| ISSN: | 0960-894X |
| Popis: | 5-Methoxycarbonyl-2′-deoxyuridine has been synthesized and incorporated in oligonucleotides. The fully protected oligonucleotides were treated with diaminoethane or diaminohexane and the oligonucleotides were deprotected and purified to give oligonucleotides carrying amino-linkers, which were further derivatized with an intercalator. Properties of these oligonucleotides are described. |
| Databáze: | OpenAIRE |
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