Synthesis of (±) 3-(6-nitro-2-quinolinyl)-[9-methyl-11C]-3,9-diazabicyclo-[4.2.1]-nonane ([11C-methyl]NS 4194)
| Autor: | Dirk Bender, Jørgen Scheel-Krüger, Donald F. Smith, Nielsen Elsebet Ostergaard, Svend Borup Jensen, Albert Gjedde, Dan Peters, Gunnar M. Olsen |
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| Rok vydání: | 2002 |
| Předmět: |
Preparative hplc
Bicyclic molecule Stereochemistry Organic Chemistry Biochemistry Chemical synthesis Analytical Chemistry chemistry.chemical_compound chemistry Carrier protein Yield (chemistry) Drug Discovery Nitro Radiology Nuclear Medicine and imaging Nonane Selectivity Spectroscopy Nuclear chemistry |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 45:181-189 |
| ISSN: | 0362-4803 |
| DOI: | 10.1002/jlcr.542 |
| Popis: | (±) 3-(6-Nitro-2-quinolinyl)-[9-methyl-11C]-3,9-diazabicyclo-[4.2.1]-nonane ([11C-methyl]NS 4194), a selective serotonin reuptake inhibitor (SSRI), was synthesised within 35 min after end of bombardment with a radiochemical purity >98%. It had a decay-corrected radiochemical yield of 7% after preparative HPLC, and a specific radioactivity around 37 GBq/μmol (EOS). A typical production starting with 40 GBq [11C]CO2 yielded 800 MBq of radiolabelled [11C-methyl]NS 4194 in a formulated solution. The synthesis of the precursor to [11C-methyl]NS 4194, (±) 9-H-3-[6-nitro-(2-quinolinyl)]-3,9-diazabicyclo-[4.2.1]-nonane, as well as the unlabelled analogue (±) 9-methyl 3-[6-nitro-(2-quinolinyl)]-3,9-diazabicyclo-[4.2.1]-nonane (NS 4194), are also described. Copyright © 2002 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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