A silyl ether-protected building block for O-GlcNAcylated peptide synthesis to enable one-pot acidic deprotection

Autor:	Bingjia Yan, Wenyi Li, Christian P. R. Hackenberger
Rok vydání:	2021
Předmět:	chemistry.chemical_compound chemistry Acid labile Block (telecommunications) Organic Chemistry Peptide synthesis Peptide cleavage Physical and Theoretical Chemistry Protecting group Biochemistry Combinatorial chemistry Silyl ether
Zdroj:	Organic & Biomolecular Chemistry. 19:8014-8017
ISSN:	1477-0539 1477-0520
DOI:	10.1039/d1ob00510c
Popis:	In this report, we introduce a novel building block for Fmoc/tBu solid phase peptide synthesis (SPPS) of β-linked O-GlcNAcylated peptides. This building block carries acid labile silyl ether protecting groups, which are fully removed under TFA-mediated peptide cleavage conditions from the resin, thus requiring fewer synthetic steps and no intermediate purification as compared to other acid or base labile protecting group strategies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5a1b7641bb00519ce9a943683a0d29c6 https://doi.org/10.1039/d1ob00510c Zobrazit plný text záznamu