Diagnostic Markers in the Head and Neck Malignancy

Autor:	Usha Sharma, Vishnu Pratap Singh Rathore
Rok vydání:	2014
Předmět:	Cluster of differentiation business.industry Mortality rate Head and neck cancer Cancer Diagnostic marker Disease medicine.disease Malignancy stomatognathic diseases Cancer research Medicine Immunohistochemistry business
Zdroj:	Journal of Advanced Oral Research. 5:17-24
ISSN:	2320-2076 2320-2068
DOI:	10.1177/2229411220140105
Popis:	Oral cancer, the largest subset of head and neck cancer, has become one of the most lethal malignancies during the last two decades. Although several diagnostic tools have been applied for the early detection of oral malignancies, it is still urgent to identify novel tumor markers. Early detection would signifi cantly decrease the mortality rate of oral cancer. Advances in understanding of the molecular mechanisms underlying oral squamous cell carcinoma (OSCC) have resulted in an increasing number of biomarkers that can be used to predict the behavior of this disease. The authors conducted a review of studies examining the role of immunohistochemistry-based protein biomarkers in predicting OSCC outcome. Recently, numerous molecular markers such as cell surface markers, intracellular markers, markers of anomalous keratinization, oncogenes, tumor suppressor genes, and proliferative markers have been investigated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5a183b325e95f9d5ba87c88976d8240f https://doi.org/10.1177/2229411220140105 Zobrazit plný text záznamu