| Autor: |
Dennis Ruff, He Sun, Liu Yang, Jing Hao, Zhi-Xin Guo, Ling-Yan Li, Ping Wang |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
The Journal of Clinical Pharmacology. 54:234-239 |
| ISSN: |
0091-2700 |
| DOI: |
10.1002/jcph.209 |
| Popis: |
This open-label, multi-dose, single-center, sequential, inpatient study evaluated the effects of a two herb combination drug (T89, Danshen plus Sanqi) on the steady-state pharmacodynamics (PD) and pharmacokinetics (PK) of warfarin in 24 healthy volunteers. Twenty-three subjects attained a stable international normalized ratio (INR) by taking warfarin alone prior to 1-week of added-on use of T89. INR was not increased after the addition of T89 for 7 days (P > .05). The 90% confidence interval (CI) of the geometric mean ratio for maximum plasma concentrations (Cmax) and area under curve (AUClast ) of both R- and S-warfarin when warfarin was administered with or without T89 was within the 0.80 to 1.25 equivalence ratio. These results indicate that T89 has no effect on the steady-state PD and PK of warfarin. Warfarin and T89 dose adjustments are not required when these two drugs are co-administrated in clinical practice. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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