| Popis: |
The effect of a new preparation of the stannous fluoride dentifrice on dental caries development was examined in an animal caries model.Golden hamsters aged 27 days were intraorally infected with cariogenic Streptococcus mutans K1-R and reared on the caries-inducing diet #2000 for 32 days. During the experimental period, the molars of the animals were brushed for 1 min. once a day, 5 days a week, with a 0.41% stannous fluoride dentifrice containing 0.88% sodium phytate, a 0.41% stannous fluoride dentifrice alone, or a placebo dentifrice. At the end of the experiment, the animals were killed, and plaque accumulation and lesions on the molars were evaluated.Daily application of the SnF2-phytate dentifrice significantly inhibited caries development and plaque formation; when compared to the placebo dentifrice-treated group, the SnF2-phytate dentifrice-treated group showed 49.2% reduction of caries development, which was much greater than the 32.2% reduction in the SnF2 dentifrice group. Similarly, reduction of plaque formation was 24.5% for the SnF2-phytate dentifrice group and 8.5% for the SnF2 dentifrice group.The high caries-inhibitory and plaque-inhibitory capacities of the SnF2-phytate dentifrice may be due to the synergistic enhancement of both the acid resistance of enamel and the anti-plaque action exerted by combination of the curative ingredients, fluoride, stannous and phytate ions. |
