Elevated basal serum tryptase and hymenoptera venom allergy: relation to severity of sting reactions and to safety and efficacy of venom immunotherapy

Autor:	Ulrich R. Müller, G Haeberli, M Brönnimann, T Hunziker
Rok vydání:	2003
Předmět:	Allergy biology Cutaneous Mastocytosis Immunology Venom Tryptase medicine.disease biology.organism_classification complex mixtures Vespula Sting Basal (phylogenetics) biology.protein medicine Immunology and Allergy Anaphylaxis
Zdroj:	Clinical & Experimental Allergy. 33:1216-1220
ISSN:	0954-7894
DOI:	10.1046/j.1365-2222.2003.01755.x
Popis:	Summary Background Mastocytosis and/or elevated basal serum tryptase may be associated with severe anaphylaxis. Objective To analyse Hymenoptera venom-allergic patients with regard to basal tryptase in relation to the severity of sting reactions and the safety and efficacy of venom immunotherapy. Methods Basal serum tryptase was measured in 259 Hymenoptera venom-allergic patients (158 honey bee, 101 Vespula). In 161 of these (104 honey bee, 57 Vespula), a sting challenge was performed during venom immunotherapy. Results Nineteen of the 259 patients had an elevated basal serum tryptase. Evidence of cutaneous mastocytosis as documented by skin biopsy was present in 3 of 16 patients (18.8%). There was a clear correlation of basal serum tryptase to the grade of the initial allergic reaction (P
Databáze:	OpenAIRE
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