Copper catalyzed 1,3-dipolar cycloaddition reaction of azides with N-(2-trifluoroacetylaryl)propargylamines
| Autor: | Marc Lemaire, Emilie David, Guillaume Pilet, Maurice Médebielle, Etsuji Okada, Sandrine Lassara, Jerome Molette, Jean-Florent Lamarque, Dai Shibata, Christophe Lamarque, Stéphane Pellet-Rostaing |
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| Rok vydání: | 2008 |
| Předmět: |
1
2 3-Triazole Organic Chemistry Triazole chemistry.chemical_element Biochemistry Medicinal chemistry Copper Cycloaddition Catalysis Inorganic Chemistry chemistry.chemical_compound chemistry Nucleophilic aromatic substitution 1 3-Dipolar cycloaddition Copper catalyzed Environmental Chemistry Organic chemistry Physical and Theoretical Chemistry |
| Zdroj: | Journal of Fluorine Chemistry. 129:788-798 |
| ISSN: | 0022-1139 |
| DOI: | 10.1016/j.jfluchem.2008.05.015 |
| Popis: | The synthesis of N -(2-trifluoroacetylaryl)propargylamines 10 – 14 and 17 is presented. The copper(I) catalyzed cycloaddition reaction of these propargylamines (dipolarophiles) with a series of azides (1,3-dipoles) 18 – 20 , 21 and 24 was found to proceed smoothly in dimethylsulfoxide at room temperature, to furnish the corresponding 1,4-disubstituted-[1,2,3]triazole derivatives 26 – 36 in moderate to good yields. |
| Databáze: | OpenAIRE |
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