Determination of Paclitaxel Solubility in Carbon Dioxide Using Quartz Crystal Microbalance
| Autor: | Shaoling Ma, Youting Wu, Zhiming Chen, Zhen Jiao |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Environmental Engineering
Materials science Chromatography Supercritical carbon dioxide General Chemical Engineering General Chemistry Quartz crystal microbalance Mole fraction Biochemistry Supercritical fluid Solvent chemistry.chemical_compound chemistry Chemical engineering Carbon dioxide Solubility Dissolution |
| Zdroj: | Chinese Journal of Chemical Engineering. 19:227-231 |
| ISSN: | 1004-9541 |
| DOI: | 10.1016/s1004-9541(11)60159-6 |
| Popis: | A quartz crystal microbalance (QCM) is used to determine the phase equilibrium of paclitaxel-carbon dioxide system in the pressure range of 0–11 MPa and at temperatures of 35 °C, 40 °C and 45 °C. The experimental results indicated that gaseous CO 2 could be absorbed poorly into paclitaxel. The swelling of paclitaxel film in CO 2 was observed before paclitaxel dissolved into supercritical carbon dioxide (ScCO 2 ) with the increase of pressure. It was found that ScCO 2 was not a good solvent for paclitaxel. The mole fraction of paclitaxel in ScCO 2 was in the range of (4.5×10 −9 )–(7.8×10 −9 ) under all our experimental conditions. Therefore, a much higher pressure than the CO 2 supercritical point and/or a cosolvent must be used in any processes wherever paclitaxel dissolution in ScCO 2 is required. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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