Bioprinted 3D calcium phosphate scaffolds with gentamicin releasing capability
| Autor: | Muhammad Atiq Ur Rehman, Luis Alberto dos Santos, Aldo R. Boccaccini, Liciane Sabadin Bertol, Ruth Meißner |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
3d printed
Materials science Scanning electron microscope Simulated body fluid chemistry.chemical_element 02 engineering and technology Calcium 01 natural sciences chemistry.chemical_compound 0103 physical sciences Materials Chemistry medicine 010302 applied physics Process Chemistry and Technology 021001 nanoscience & nanotechnology Phosphate Surfaces Coatings and Films Electronic Optical and Magnetic Materials Gentamicin Sulfate chemistry Ceramics and Composites Gentamicin 0210 nano-technology Drug carrier Nuclear chemistry medicine.drug |
| Zdroj: | Ceramics International. 45:7090-7094 |
| ISSN: | 0272-8842 |
| DOI: | 10.1016/j.ceramint.2018.12.212 |
| Popis: | We investigated the suitability of 3D printed calcium phosphate scaffolds as drug carriers. The 3D powder printing process utilized α-tricalcium phosphate (α-TCP) as a solid phase and deionized water with 2.5% disodium hydrogen phosphate as a setting accelerator. The antibiotic gentamicin sulfate was incorporated by mixing it into α-TCP powder before printing. Two different concentrations of gentamicin (3 wt%, 7 wt%) were used to study the correlation between drug release kinetics and gentamicin content in the scaffolds. The scaffolds were hardened at 100% humidity. The synthesized scaffolds were characterized in terms of morphology, composition, mechanical strength, in vitro bioactivity and drug release kinetics. X-ray diffraction (XRD) analysis revealed that the α-TCP converted into calcium deficient hydroxyapatite (CDHA) during the printing process. Scanning electron microscopy (SEM) showed the typical needle-like structure of CDHA. Gentamicin release was investigated for a period of two weeks with an initial burst release. The produced scaffolds formed calcium enriched apatite crystals on their surface after three days of incubation in simulated body fluid. |
| Databáze: | OpenAIRE |
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