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Objective This study aims to estimate the contribution of 11 polymorphisms in the genes SLC6A4 (5HTT), HTR1A, HTR2A, HTR1B, SLC6A3 (DAT1), DRD4, DRD2, COMT and BDNF to suicidal behavior and severity of symptoms of depression and anxiety in Russian population.Methods The study was performed on 100 patients with repeated suicide attempts and 154 controls. The SNP and VNTR genotyping was carried out using locus-specific PCR. Logistic regression approach was applied to establish associations between gene polymorphisms and risk of suicidal attempts. Negative binomial regression was used to analyze association between genotypes and count variables: severity of depressive symptoms, personal anxiety and situational anxiety. Results We have first found an association between SLC6A3 (DAT1) 40 bp VNTR locus and suicidal behavior. This association was significant in the co-dominant (P = 0.006), dominant (P = 0.001), over-dominant (P = 0.004) and log-additive (P = 0.004) models, LL genotype played a protective role (OR = 0.48, 0.29–0.82). Difference in the genotypes distribution of COMT rs4680 was significant in the co-dominant (P = 0.04), dominant (P = 0.013) and log-additive (P = 0.02) models, and AA genotype might protect against suicide (OR = 0.49, 0.26–0.91). SLC6A4 5-HTTLPR+rs25531 locus was significant only in the recessive model (P = 0.024) and also affected the severity of symptoms of depression (P = 0.044) and personal anxiety (P = 0.029). Conclusions Our results suggest that allelic variants of SLC6A3, COMT and SLC6A4 genes might be considered as risk factors for suicidal attempts. |
