Anti-hypertensive, anti-diabetic, hypocholesterolemic and antioxidant properties of prickly pear nopalitos in type 2 diabetic rats fed a high-fat diet
| Autor: | Nour el Imane Harrat, Myriem Lamri-Senhadji, Fatima Bensalah, Hadjera Chekkal, Sabrine Louala, Fouad Affane |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
0303 health sciences medicine.medical_specialty Nutrition and Dietetics 030309 nutrition & dietetics Thiobarbituric acid Cholesterol Glutathione peroxidase Adipose tissue Type 2 diabetes Streptozotocin medicine.disease 03 medical and health sciences chemistry.chemical_compound Endocrinology Insulin resistance chemistry Internal medicine medicine 030304 developmental biology Food Science Lipoprotein medicine.drug |
| Zdroj: | Nutrition & Food Science. 49:476-490 |
| ISSN: | 0034-6659 |
| Popis: | PurposeThe purpose of this study was to investigate the effects of prickly pear (Opuntia ficus indica(OFI)) nopalitos on body weight, food consumption, arterial blood pressure, glucidic homeostasis, cholesterol metabolic pathway and tissues redox status in type 2 diabetic (T2D) rats fed a high-fat diet (HFD).Design/methodology/approachRats were fed by a HFD containing 30 per cent sheep fat for 10 weeks, after which they were rendered diabetic by an injection of a low dose of streptozotocin (STZ) (35 mg/kg). The diabetic rats were then divided into two groups. The first group consumed the HFD supplemented with 5 per cent (g/100 g diet) of freeze-driedOFInopalitos (HFD-OFI), and the second group received the HFD without supplementation (HFD).FindingsOFInopalitos treatment decreased significantly arterial diastolic (−20%;p= 0.0001) and systolic (−16%;p= 0.0001) pressures, glycemia (−14%;p= 0.03), insulinemia (−50%;p= 0.04), glycated hemoglobin (−49%;p= 0.003), homeostasis model assessment insulin resistance (−67%;p= 0.03), cholesterolemia (−31%;p= 0.003), very-low and low-density lipoprotein cholesterol (−38%;p= 0.002 and −63%p= 0.0002, respectively); thiobarbituric acid reactive substances and lipid hydroperoxide contents, respectively, in liver (−26%p= 0.02, −20%p= 0.02), adipose tissue (−30%p= 0.002, −25%p= 0.001), muscle (−29%p= 0.003, −25%p= 0.008) and kidney (lipid hydroperoxides only (−28%;p= 0.001) but increased high-density lipoprotein (HDL2) cholesteryl esters (+61%;p= 0.0001), serum lecithin: cholesterol acyltransferase activity (+21%;p= 0.006) and antioxidant enzymes activities (superoxide dismutase, glutathione peroxidase and catalase) of some tissues (liver, adipose tissue, muscle and kidney).Originality/valueFreeze-driedOFInopalitos improves arterial blood pressure, glycemic control, metabolic pathway of cholesterol and redox status in T2D rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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