Effects of Imipramine and Bupropion on the Duration of Immobility of ACTH-Treated Rats in the Forced Swim Test: Involvement of the Expression of 5-HT2A Receptor mRNA
| Autor: | Toshiaki Sendo, Toshiaki Miyazaki, Yoshihisa Kitamura, Yoshika Fujitani, Kazuhiko Shibata, Kouhei Kitagawa, Hidenori Sagara, Hiromu Kawasaki, Yutaka Gomita |
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| Rok vydání: | 2008 |
| Předmět: |
Pharmacology
Bupropion medicine.medical_specialty business.industry Pharmaceutical Science General Medicine Adrenocorticotropic hormone Imipramine Endocrinology Monoamine neurotransmitter Internal medicine medicine Serotonin Reuptake inhibitor business 5-HT receptor medicine.drug Behavioural despair test |
| Zdroj: | Biological & Pharmaceutical Bulletin. 31:246-249 |
| ISSN: | 1347-5215 0918-6158 |
| DOI: | 10.1248/bpb.31.246 |
| Popis: | We examined the effect of chronic administration of imipramine and bupropion, monoamine reuptake inhibitors, on the duration of immobility in the forced swim test and serotonin (5-HT)(2A) receptor function in the form of 5-HT(2A) receptor mRNA levels in rats chronically treated with adrenocorticotropic hormone (ACTH). The immobility-decreasing effect of bupropion without imipramine did not influence the chronic ACTH treatment. The effect on the expression of 5-HT(2A) receptor mRNA of chronic ACTH treatment was decreased by bupropion, but not imipramine. These results suggest that bupropion has the effect of reducing immobility time in the forced swim test in the tricyclic antidepressant-resistant depressive model induced by chronic ACTH treatment in rats, and that decreased 5-HT(2A) receptor mRNA levels may be involved in this phenomenon. |
| Databáze: | OpenAIRE |
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