Hypoxia-Responsive 19F MRI Probes with Improved Redox Properties and Biocompatibility
| Autor: | José S. Enriquez, Da Xie, Vikraant Kohli, Emily L. Que, Jeffrey J. Luci, Seyong Kim, Arnab Banerjee, Meng Yu |
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| Rok vydání: | 2017 |
| Předmět: |
inorganic chemicals
010405 organic chemistry Chemistry Fluorine-19 Magnetic Resonance Imaging Fluorine-19 NMR 010402 general chemistry 01 natural sciences Redox 0104 chemical sciences Inorganic Chemistry chemistry.chemical_compound Nuclear magnetic resonance Moiety Molecule Physical and Theoretical Chemistry Linker Ethylene glycol Coordination geometry |
| Zdroj: | Inorganic Chemistry. 56:6429-6437 |
| ISSN: | 1520-510X 0020-1669 |
| Popis: | 19F magnetic resonance imaging (MRI), an emerging modality in biomedical imaging, has shown promise for in vitro and in vivo preclinical studies. Here we present a series of fluorinated Cu(II)ATSM derivatives for potential use as 19F magnetic resonance agents for sensing cellular hypoxia. The synthesized complexes feature a hypoxia-targeting Cu2+ coordination core, nine equivalent fluorine atoms connected via a variable-length poly(ethylene glycol) linker. Introduction of the fluorine moiety maintains the planar coordination geometry of the Cu2+ center, while the linker length modulates the Cu2+/+ reduction potential, 19F NMR relaxation properties, and lipophilicity. In particular, the 19F NMR relaxation properties were quantitatively evaluated by the Solomon–Bloembergen model, revealing a regular pattern of relaxation enhancement tuned by the distance between Cu2+ and F atoms. Finally, the potential utility of these complexes for sensing reductive environments was demonstrated using both 19F MR phantom i... |
| Databáze: | OpenAIRE |
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