Effects of Carbopol® 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study
| Autor: | Bo-Zhen Wang, Chaoshuang Hao, Ouyang Wuqing, Wei Yunpeng, Shahid Faraz Syed, Zheng Yin, Yan-Hong Shang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Materials science
Biophysics Pharmaceutical Science Bioengineering 02 engineering and technology Pharmacology Citral 030226 pharmacology & pharmacy Biomaterials 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Dermis Drug Discovery medicine Stratum corneum Transdermal integumentary system Organic Chemistry General Medicine Permeation 021001 nanoscience & nanotechnology medicine.anatomical_structure chemistry Drug delivery Terbinafine 0210 nano-technology Ex vivo medicine.drug |
| Zdroj: | International Journal of Nanomedicine. 11:5971-5987 |
| ISSN: | 1178-2013 |
| DOI: | 10.2147/ijn.s119286 |
| Popis: | Nanoemulsions (NEs) are used as transdermal drug delivery systems for systematic therapeutic purposes. We hypothesized that the skin permeation profile of an NE could be modulated by incorporating it into a hydrogel containing differing proportions of thickening agent. The objectives of this study were as follows: 1) to determine the stability and skin irritability of NE gels (NGs) containing 1%, 2%, and 3% (w/w) Carbopol® 934 (CP934) (termed NG1, NG2, and NG3, respectively); 2) to compare the skin permeation profiles and drug deposition patterns of the NGs; and 3) to visualize the drug delivery routes of the NGs. Terbinafine and citral were incorporated into the NGs as model drugs. Ex vivo skin permeation tests indicated that the percutaneous flux rates of terbinafine decreased in the order NE (215 μg/cm2) > NG1 (213 μg/cm2) > NG2 (123 μg/cm2) > NG3 (74.3 μg/cm2). The flux rates of citral decreased in the order NE (1,026 μg/cm2) > NG1 (1,021 μg/cm2) > NG2 (541 μg/cm2) > NG3 (353 μg/cm2). The NGs accumulated greater amounts of the drugs in the stratum corneum and less in the epidermis/dermis than did the NE (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|