A liposomal dispersion formulation of propofol: formulation, pharmacokinetics, stability, and identification of an oxidative degradant

Autor: G. M. Jensen, S. W. Bunte, H. Pham, C. S. Ashvar, S. Yang, N. Hu, T. H. Bunch, C. R. Skenes, J. Kennavane, C. D. Barzak, R. L. Fahrner
Rok vydání: 2007
Předmět:
Zdroj: Theoretical Chemistry Accounts. 119:291-296
ISSN: 1432-2234
1432-881X
Popis: Propofol is a common and highly effective anesthetic. Commercially available formulations of propofol, which is only sparingly soluble in aqueous systems, utilize emulsion technology. A liposome based dispersion formulation of propofol has been produced which exhibits good long term colloidal and chemical stability and pharmacokinetcs indistinguishable from the emulsion systems. Inclusion of 0.01% ascorbic acid in the final formulation arrests the growth of an oxidative degradant of propofol both during production and on stability. This degradant is identified as being the dimer 4,4′-dihydroxy-3,3′, 5,5′-tetraisopropylbiphenyl by mass spectroscopy and comparison of the infrared spectrum of the purified degradant to predicted spectra generated using density functional theory.
Databáze: OpenAIRE
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