Management of sodium metabolism derangements in children treated for hypothalamic-hypophyseal tumors
| Autor: | Roberto Lala, Marialia Repici, Alessandro Mussa, Ludovica Fiore, Daniele Tessaris, Francesca Verna, Gerdi Tuli, Patrizia Matarazzo |
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| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Journal of Pediatric Biochemistry. :289-296 |
| ISSN: | 1879-5404 1879-5390 |
| Popis: | Hyponatremia and hypernatremia, common electrolyte abnormalities in children hospitalized for intracranial diseases, are life-threatening events. Diagnosis and adequate treatment of hypo- and hypernatremia are mandatory to prevent neurological sequelae. We report ante-and post-hypophyseal dysfunctions, disabilities and acute sodium metabolism derangements in 16 children affected by hypothalamic-hypophyseal tumors treated by neurosurgery and/or chemotherapy during a long-lasting follow-up. We compare acute hypo- and hypernatremic episodes during surgery between these patients, treated with a specific hormonal and infusive protocol (protocol A), and a previous cohort of patients, affected by similar tumors, treated with a previously published protocol (protocol B). All patients showed multiple or isolated pituitary dysfunctions and disabilities before chemotherapy and/or surgical treatment that worsened during the follow-up period. We found a statistical significant decrease of hyponatremic intra-operative acute events in children treated with protocol A. Sodium metabolism derangements complicating the course of hypothalamic-hypophyseal tumors can be partially prevented with specific per-operative protocols. Aim of this study is to present a new sodium metabolism derangements management in children treated for hypothalamic-hypophyseal tumors and to compare this with a previous one. |
| Databáze: | OpenAIRE |
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