Calciumantagonisten in der Therapie der Hypertonie
| Autor: | August Heidland, R. M. Schäfer, Walter H. Hörl, Ekkehart Heidbreder |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
medicine.medical_specialty
Vascular smooth muscle Aldosterone business.industry Hemodynamics General Medicine chemistry.chemical_compound medicine.anatomical_structure chemistry Nifedipine Internal medicine Drug Discovery Renin–angiotensin system Vascular resistance medicine Cardiology Molecular Medicine Verapamil Diltiazem business Genetics (clinical) medicine.drug |
| Zdroj: | Klinische Wochenschrift. 61:633-640 |
| ISSN: | 1432-1440 0023-2173 |
| DOI: | 10.1007/bf01487579 |
| Popis: | Calcium antagonists (nifedipine, verapamil, diltiazem) are potent vascular smooth muscle relaxants. Experimental and clinical investigations provide growing evidence that they are effective in acute and (sub)chronic therapy of arterial hypertension by lowering peripheral vascular resistance and improvement of altered hemodynamics — independent from pathogenesis of hypertension. Due to its prompt and profound hypotensive action, sublingual or oral nifedipine has been used successfully in hypertensive crises. The hypotensive effect usually correlates closely with the severity of hypertension and is nearly absent in normotensive controls. Since the blood pressure drop may occasionally result in absolute or relative hypotension, the initial dose should be as low as possible. The activation of the adrenergic and renin angiotensin systems seen after nifedipine administration is less pronounced after chronic administration of the drug and is nearly absent after verapamil and diltiazem. Plasma aldosterone concentrations remain constant or are slightly decreased. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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