Free radical scavenger, edaravone, reduces myocardial infarct size in rabbits

Autor: Chen Xuehai, Onogi Hirohito, Ninguan Wang, Minatoguchi Shinya, Misao Yu, Nagai Hiroshi, Fujiwara Hisayoshi, Lu Chuanjiang, Takemura Genzou, Arai Masazumi
Rok vydání: 2004
Předmět:
Zdroj: Journal of Cardiac Failure. 10:S158
ISSN: 1071-9164
DOI: 10.1016/j.cardfail.2004.08.014
Popis: Background: There is controversy whether free radical scavengers reduce myocardial infarct size. Among many free radical scavengers, edaravone has been reported to be effective for the treatment of cerebral infarction. Therefore, we hypothesized that edarabon may also be effective for the treatment of myocardial infarction. Methods: Japanese white rabbits underwent a 30-min ischemia followed by a 48-hr or 14 day reperfusion. In the edaravone group, edaravone (a free radical scavenger, 3 mg/kg, i.v.) was administered at 10 min before reperfusion. In the control group, saline was administered at 10 min before reperfusion. The heart was excised 48 hours after reperfusion or 14 days after reperfusion. The risk area was determined by Evans blue dye and the infarct area was determined by TTC staining. The infarct size as a percentage of the risk area was obtained. Results: The infarct size as a percentage of the area at risk was significantly reduced in the edaravone group as compared with the control group both at 48 hours and 14 days after reperfusion. Smaller left ventricular (LV) dimension and increased LV ejection fraction at 14 days after infarction assessed by echocardiography were observed in the edaravone group than in the control group. Conclusion: Free radical scavenger edaravone reduces the infarct size and improves cardiac function and remodeling in rabbits.
Databáze: OpenAIRE
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