Comparison of 68Ga-EDTA, [l-11C]α-aminoisobutyric acid, and [99mTC]sodium pertechnetate in an experimental blood-brain barrier lesion
| Autor: | Linda Dees Blair, Billy L. Byrd, Tan Tan Sun, Lee C. Washburn |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
medicine.diagnostic_test
Osmotic concentration Chemistry business.industry Blood–brain barrier Aminoisobutyric acid Sodium pertechnetate Lesion chemistry.chemical_compound medicine.anatomical_structure Positron emission tomography medicine Radiology Nuclear Medicine and imaging Mannitol medicine.symptom Nuclear medicine business Technetium-99m medicine.drug |
| Zdroj: | International Journal of Nuclear Medicine and Biology. 12:267-269 |
| ISSN: | 0047-0740 |
| DOI: | 10.1016/0047-0740(85)90178-0 |
| Popis: | Unilateral opening of the blood-brain barrier (BBB) in rats, induced by infusion of a hyperosmotic solution of mannitol into the left internal carotid artery, was applied to compare 68 Ga-EDTA, [1- 11 C]α-aminoisobutyric acid (using the long-lived 14 C-labeled analog), and [ 99m Tc]sodium pertechnetate as agents for diagnosis of BBB disruption. Of the three agents and two time intervals studied, 68 Ga-EDTA at 30 min postinjection gave the highest target-to-nontarget ratio. In addition, 68 Ga-EDTA, unlike commonly used 99m Tc)sodium pertechnetate, can be used in conjunction with positron emission tomography, which could make possible earlier and better assessment of BBB defects using 68 Ga-EDTA. |
| Databáze: | OpenAIRE |
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