| Popis: |
Recent findings have provided strong evidence in support of a functional role of the “erythrocyte receptor” of human T-lymphocytes in T-cell activation. Thus, binding of appropriate ligands (erythrocytes or monoclonal antibodies) to the CD2 molecule, as this receptor is now called, can either block (Palacios and Martinez-Maza 1982; Martin et al. 1983; Krensky et al. 1983) or stimulate (Larsson et al. 1978; Meuer et al. 1984) T-cell proliferation and expression of T-cell function. We have previously suggested that CD2 is a cell interaction molecule, the natural ligand of which is expressed on cells with which T-lymphocytes interact during immune responses (Hunig 1985, 1986). Since the CD2 molecule had previously been characterized by the T11 antigen(s), we have named this ligand T11 target structure or T11TS. |
