Regiospecific Synthesis of 5-(1H-Indol-2-yl)-1- and 2-Methyl-6,7-dihydro-2H-indazole Isomers

Autor:	Kurt A. Josef, Edward R. Bacon, Ming Tao, Reddeppareddy Dandu, Robert L. Hudkins
Rok vydání:	2007
Předmět:	Indazole Isotopes of lithium chemistry.chemical_element General Medicine medicine.disease Medicinal chemistry Catalysis chemistry.chemical_compound chemistry Suzuki reaction medicine Structural isomer Lithium Dehydration Palladium
Zdroj:	ChemInform. 38
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200732124
Popis:	A regiospecific approach to each N-methyl-5-(1H-indol-2-yl)-6,7-dihydro-2H-indazole isomer is reported. The 1-methyl isomer 1 was prepared from 5-bromo-1-methyl-6,7-dihydro-1H-indazole 3 and indole-2-boronate 5 by palladium catalyzed Suzuki coupling. The 2-methyl regioisomer 2 was synthesized via addition of lithium (1-carboxylato-1H-indole-2-yl)lithium 6 with 2-methyl-2,4,6,7-tetrahydro-indazol-5-one 8 followed by acid catalyzed dehydration.
Databáze:	OpenAIRE
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