Synthesis and conformational analysis of isomeric 3-propananilidotropanes

Autor:	Thomas N. Riley, Jerome R. Bagley
Rok vydání:	1977
Předmět:	chemistry.chemical_compound chemistry Stereochemistry Organic Chemistry Cyclohexane conformation Tropane Piperidine Ring (chemistry)
Zdroj:	Journal of Heterocyclic Chemistry. 14:599-602
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.5570140412
Popis:	The isomeric 3-anilino and 3-propananilidotropanes have been synthesized and obtained in isomerically pure form. The configurations and solute conformations of these isomers were studied via glc and nrar analysis. The 3β-isomers have been shown to exist in the normal piper-idine chair conformation whereas the 3α-anilino tropane exists in a flattened piperidine chair conformation and the 3α-propananilidotropane isomer preferentially exists in a conformation in which the piperidine ring system is a boat.
Databáze:	OpenAIRE
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