Dendrimers of Vaccines Consisting of Tumor-Associated Glycopeptide Antigens and T Cell Epitope Peptides

Autor:	Stefanie Keil, Horst Kunz, Anton Kaiser, Fauziya Syed
Rok vydání:	2009
Předmět:	Chemistry T cell Organic Chemistry Antigen presentation Toxoid complex mixtures Molecular biology Catalysis Glycopeptide Epitope medicine.anatomical_structure Antigen Macrophage-1 antigen medicine MUC1
Zdroj:	Synthesis. 2009:1355-1369
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-0028-1088033
Popis:	According to the principle of multiple antigen presentation (MAP), a di-lysyl lysine core was used for the synthesis of tetramers of a glycododecapeptide antigen from the tandem-repeat sequence of the tumor-associated mucin, MUC1, which carries a sialyl T N -antigen saccharide side chain. The methodology was extended to the analogous construction of a tetrameric vaccine consisting of a T cell epitope from tetanus toxoid and the sialyl T N -glycododecapeptide of MUC 1.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::597b362feb1eacebc996062190319132 https://doi.org/10.1055/s-0028-1088033 Zobrazit plný text záznamu