Anxiolytic and Anti-Depressant Effects of AgNPs Fabricated Using Diosgenin

Autor:	Lakshmi Prabha, Uma Maheswari Rajadurai, Joe Antony, Veeraiyan Nandagopalan, Achiraman, Abirami Hariharan
Rok vydání:	2019
Předmět:	Elevated plus maze Antioxidant Chemistry medicine.drug_class medicine.medical_treatment Diosgenin Pharmacology Anxiolytic Silver nanoparticle chemistry.chemical_compound medicine Antidepressant human activities Diazepam medicine.drug Behavioural despair test
Zdroj:	SSRN Electronic Journal.
ISSN:	1556-5068
DOI:	10.2139/ssrn.3370113
Popis:	The current study was carried out to study the anxiolytic and anti-depressant effect of silver nanoparticles (AgNPs) synthesized using diosgenin at varying doses applying Elevated Plus Maze (EPM) and Forced swimming test (FST). Diazepam and Imiprazole were used as standards. Experimental mice spent more time in open arm after treatment in EPM. Significant dose dependent decline in immobility time was observed in FST. Antioxidant activity could be the possible rationale behind the observed anxiolytic and antidepressant effects of diosgenin and its AgNPs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5972d990c73cc49a8995b6268483e5a7 https://doi.org/10.2139/ssrn.3370113 Zobrazit plný text záznamu