New approaches to prediction and treatment of advanced gastric cancer based on molecular-biological parameters

Autor:	M. V. Savostikova, A. V. Karpukhin, M. N. Narimanov, Evgeniya S. Fedoseeva, A. A. Pashaev, F M Kipkeeva, S. S. Kirichenko, T. A. Muzaffarova
Rok vydání:	2017
Předmět:	Oncology medicine.medical_specialty business.industry Internal medicine Medicine General Medicine Advanced gastric cancer business
Zdroj:	Clinical Medicine (Russian Journal). 94:812-820
ISSN:	2412-1339 0023-2149
DOI:	10.18821/0023-2149-2016-94-11-812-820
Popis:	This review is designed to discuss possibilities for the treatment of advanced gastric cancer with reference to the prognostic and predictive value of molecular-biological parameters and the influence of hereditary predisposition to the development of neoplastic process. The data on modern pharmacotherapy of this disease based on the knowledge of molecular-biological parameters are presented including the following markers: HER2/neu, VGFR, c-met, TUBB3, CDH-1, BRCA-1, EGFR, TGF-ß, p53, Ki67 and PCNA. It is emphasized that the role of molecular-biological parameters associated with advanced gastric cancer is ambiguous. The prognostic and predictive significance of some of the markers is confirmed while that of others remains to be elucidated and requires further research.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::596fe43dc285b74cafa9d2dc169ed149 https://doi.org/10.18821/0023-2149-2016-94-11-812-820 Zobrazit plný text záznamu