| Autor: |
null Adil Shaikh, null Dr Md Farooq Ahmed, null Prof. Rajshekhar Bhande, null Dr K. Sreenivas Rao, null Dr M. A. Aleem |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
International Journal of Advanced Research in Science, Communication and Technology. :440-447 |
| ISSN: |
2581-9429 |
| DOI: |
10.48175/ijarsct-7198 |
| Popis: |
Nigella sativa is commonly known as black seed traditionally used in various diseases. In this investigation to find out gastroprotective activity in rats. This paper reports on the investigation of the acute toxicity and gastroprotective effect of the Nigella sativa seed extract on Ibuprofen-induced ulcers. The extract did not show acute toxicity in mice treated with 2 g/kg p.o., but exhibited significant antiulcer activity in rats at doses of 300, and 400mg/kg p.o., with the reference drug omeprazole. The results provide evidence for the usage of Nigella sativa as angastroprotective agent, which has been based previously only on ethnopharmacological claims. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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