Concentración sérica de GHBP, IGF-1 e IGFBP-3 en niños con talla baja familiar y con talla normal

Autor:	Grupo Andaluz de Endocrinología Pediátrica, López-Canti Lf, Lechuga Campoy Jl, Martínez-Aedo Ollero Mj, López-Siguero Jp, del Valle Núñez Cj, Espigares Martín R
Rok vydání:	2004
Předmět:	medicine.medical_specialty business.industry Growth factor medicine.medical_treatment Bone age General Medicine Serum samples Central laboratory Growth velocity Endocrinology Growth hormone-binding protein Internal medicine medicine Binding protein 3 business Body mass index
Zdroj:	Medicina Clínica. 123:452-455
ISSN:	1578-8989 0025-7753
Popis:	BACKGROUND AND OBJECTIVE Growth hormone binding protein (GHBP), insuline-like growth factor 1 (IGF-1) and insuline-like growth factor binding protein 3 (IGFBP-3) serum concentrations were studied in familial short-statured patients (FSS) and age-matched normal-statured subjects. The aim of the study was to ascertain whether differences in growth factors concentrations between groups could be shown and whether they may contribute to explaining the different patterns of growth in both groups. SUBJECTS AND METHOD Serum samples of 38 FSS patients (20 boys) and 31 normal-statured subjects (15 boys) in Tanner I stage (prepubertal), were analysed in a central laboratory. All auxological parameters (height, growth velocity, target height, body mass index (BMI) and biochemical parameters (IGF-1 and IGFBP-3) were standardised for age and sex-matched subjects. GHBP values were expressed as percentage of specific binding. RESULTS The studied populations were similar and no statistically-significant differences in chronological age, bone age and BMI were found. Height, growth velocity and target height were significantly lower in FSS patients compared with normal subjects (p < 0.0001). IGF-1, IGFBP-3 and GHBP concentrations were significantly lower in the FSS group (p < 0.01). Correlations were found between IGF-1 and IGFBP-3 (r = 0.56; p = 0.0004) and between IGF-1 and GHBP (r = 0.34; p = 0.03) in the FSS group. However, in the normal-statured group only BMI and GHBP were correlated (r = 0.5; p = 0.02). CONCLUSIONS These results strongly support the importance of the GH/IGF-1 functional axis in the pattern of growth and probably contribute to understanding of the pathophysiologic basis of the auxological differences found between groups.
Databáze:	OpenAIRE
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