Synthesis and biological activity of a series of 4-aryl substituted benz[b]azepines: Antagonists at the strychnine-insensitive glycine site

Autor:	Linda M. Pullan, Jeffrey M. Goldstein, James R. Damewood, Paul F. Jackson, Jeffrey A. McKinney, Timothy Davenport, Gregory G. Harris, Laura Garcia, Margaret G. Melville, Marc J. Chapdelaine
Rok vydání:	1995
Předmět:	Chemistry Stereochemistry Aryl Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biological activity Strychnine Biochemistry chemistry.chemical_compound In vivo Drug Discovery Glycine Molecular Medicine Azepine Molecular Biology Glycine receptor Derivative (chemistry)
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 5:3097-3100
ISSN:	0960-894X
Popis:	A series of 4-arylbenz[b]azepine analogs were prepared and shown to act as antagonists at the strychnine-insensitive glycine receptor. The heteroaryl substituted benz[b]azepine derivative 11 also showed excellent in vivo activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::59678d848e45b17ab696e2481e0e42ae https://doi.org/10.1016/0960-894x(95)00544-0 Zobrazit plný text záznamu Full Text from ScienceDirect