| Autor: | R.L. Renaud, John F. Leatherland, P. K. Reddy, M.N. Khan |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
endocrine system
medicine.medical_specialty animal structures biology urogenital system Physiology animal diseases Embryogenesis Embryo General Medicine Metabolism Aquatic Science biology.organism_classification digestive system Biochemistry chemistry.chemical_compound Endocrinology Biosynthesis chemistry Internal medicine medicine Hydroxyprogesterone Rainbow trout Androstenedione Salvelinus |
| Zdroj: | Fish Physiology and Biochemistry. 16:197-209 |
| ISSN: | 0920-1742 |
| DOI: | 10.1023/a:1007725832235 |
| Popis: | The effect of cortisol on the in vitro metabolism of [3H]17-hydroxyprogesterone ([3H]17OHP) was studied during embryonic development of Arctic charr (Salvelinus alpinus) and rainbow trout (Oncorhynchus mykiss). In the absence of cortisol, rainbow trout embryos metabolized [3H]17OHP largely to androstenedione (A4) and androstenetrione (11-KA) with a minor conversion to 17,20s-dihydroxy-4-pregnen-3-one (17,20P). In the presence of cortisol, this biosynthesis was inhibited. On the other hand, cortisol had no apparent inhibitory effect on the nature of metabolism of [3H]17OHP by Arctic charr embryos. In these embryos [3H]17OHP was metabolized mainly to 17,20P with a minor conversion to A4 and without the formation of 11-KA that was seen in rainbow trout. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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