Fabrication of innovative ZnO nanoflowers showing drastic biological activity
| Autor: | Shaikh M. Mobin, Archana Chaudhary, Kshipra Kapoor, Vinay Sharma, Akbar Mohammad, Veenu Mishra |
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| Rok vydání: | 2016 |
| Předmět: |
pBluescript
biology Chemistry Nanotechnology Biological activity 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology biology.organism_classification Cleavage (embryo) 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences chemistry.chemical_compound Escherichia Materials Chemistry 0210 nano-technology Oxidative cleavage Bacteria DNA Strong binding |
| Zdroj: | New Journal of Chemistry. 40:2145-2155 |
| ISSN: | 1369-9261 1144-0546 |
| DOI: | 10.1039/c5nj02391b |
| Popis: | The present study deals with the synthesis of ZnO nanoflowers (ZnO-1 and ZnO-2) at room temperature using new structurally characterized single molecular precursors (1 and 2). 1, 2 and ZnO-1 were explored for their potential to reduce the viability of the Gram-negative bacteria Escherichia coli.1 and 2 were found to be promising antibacterial agents, while the ZnO nanoflowers demonstrated a relatively non-toxic nature. 1, 2 and ZnO-1 were further evaluated for DNA binding and cleavage behaviour. 1 and 2 showed strong binding affinity towards CT-DNA compared to ZnO-1. In addition, all the three compounds demonstrated oxidative cleavage of pBluescript plasmid DNA in the presence of H2O2. |
| Databáze: | OpenAIRE |
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