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Objective We aimed to assess urinary leukotriene (ULT) changes during asthma attacks and to evaluate the effect of anti-inflammatory drugs on ULT levels. Methods A randomized prospective case-control study was mediated. The study included 30 asthmatic patients (19 male and 11 female), aging 8–14 years. Patients were diagnosed as partly controlled asthmatic individuals. Twenty age-matched and sex-matched healthy children were also included as controls. Participants were subjected to thorough history taking, clinical examination, pulmonary function testing, ULTB4 assessment and blood eosinophilic count. Medical treatment for 6 weeks was mediated. Tests were repeated for evaluation. Results Significant improvement was noted with regard to the spirometric parameters FEV1%, FVC%, PEFR% and FEF 25–75% (P Conclusion Using the receiver-operating characteristic curve for the evaluation of asthma, ULTB4 was as a reliable marker for asthma monitoring and follow-up. |
