Risks of Viral Hepatitis B Transmission in Mother-to-Infant of Pregnant Women Carriers of Chronic Viral Hepatitis B in Cote d’Ivoire
| Autor: | Aristide Tchimou, Henriette Kissi Anzouan-Kacou, Stanislas Doffou, Aboubakar Demba Bangoura, D. H. Kouamé, Karidiatou Diallo, Alain Attia, Fulgence Bathaix Yao, Mahassadi Kouamé Alassan, Thérèse Ndri Yoman |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pediatrics medicine.medical_specialty Transmission (medicine) business.industry Obstetrics 030106 microbiology virus diseases Cote d ivoire Viral hepatitis b digestive system diseases Serology 03 medical and health sciences 0302 clinical medicine medicine Marital status 030212 general & internal medicine Chronic viral hepatitis B Prospective cohort study business Viral load |
| Zdroj: | Open Journal of Gastroenterology. :206-215 |
| ISSN: | 2163-9469 2163-9450 |
| DOI: | 10.4236/ojgas.2017.77022 |
| Popis: | The aim of this study was to identify the risk factors of mother-to-child transmission of HBV in positive Ag Hbs pregnant women in Cote d’Ivoire. Methods: This was a transversal prospective study that took place over a period of 7 months (from February 2016 to August 2016) in 2 university hospital and 2 private clinics. We consecutively recruited 91 pregnant women who were positive for HBs Ag in prenatal consultations. For each pregnant woman record included in the study, we provided Socio-demographic (Age, marital status, education level, social rank, gravidity, parity) and biological data (HBs Ag, Anti-HBc Total Ac, Hbe Ag, Ac anti-Hbe Ac, DNA-VHB, Ac anti-HCV Ac, retroviral serology, transaminases). All of these data were collected using a survey sheet developed for the study. Results: The age of our pregnant women HBs positive ranged from 18 years to 44 years with a mean age of 30.10 years. The age group from 20 to 39 years was the most represented with a frequency of 92.31%. Almost of all positive HBs Ag pregnant women was HBe Ag negative, only 3.3% was HBe Ag positive. The viral load above 2000 IU/ml was found in 21 (23.03%) patients. There were 4 co-infected patients, which 3 HBV-HIV and 1 HBV-HCV. Only 19 (20.88%) pregnant HBs Ag positive women were able to bring back the supplementary virological assessment within a period less than one month. Conclusion: According to our work the virologic profile of positive HBs Ag in pregnant women in Cote d’Ivoire is characterized by an important viral replication objectified by a high viral load in about 23% pregnant women, a negativity of HBe antigen in 96.6% of them. |
| Databáze: | OpenAIRE |
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