| Autor: |
Karlheinz Voigt, Mathias Dewald, Hans A. Braun, Martin T. Huber |
| Rok vydání: |
1997 |
| Předmět: |
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| Zdroj: |
AIP Conference Proceedings. |
| DOI: |
10.1063/1.54194 |
| Popis: |
Many neurons, in various areas of the nervous system, exhibit spontaneous and intrinsic oscillations of their membrane potential or can develop oscillations on depolarization. Here we consider so-called subthreshold oscillations which operate close to the threshold of spike-generation. To analyze the principle neuromodulatory properties of such neuronal mechanisms we developed a computer model consisting of only a mnimal set of ironic conductances but which nevertheless attains subthreshold membrane potential oscillations of variable frequency and amplitude. With the addition of stochastic components, the oscillations generate typical impulse patterns which originate from a mixture of spike-triggering and subthreshold oscillations. The spiking probability thereby depends on the oscillation and noise parameters. According to the experimental data, the model can be tuned from complete silence to tonic firing with maximum sensitivity between these two extremes. Range and steepness of the activity and sensiti... |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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