Microwave accelerated synthesis of isoxazole hydrazide inhibitors of the system xc- transporter: Initial homology model

Autor:	Jayme L. Newell, Sarjubhai A. Patel, Richard J. Bridges, Joseph Mirzaei, Michael Braden, Nicholas R. Natale, Stephen A. Smith, John Rudolph, Afnan A. Matti
Rok vydání:	2013
Předmět:	Stereochemistry Antiporter Organic Chemistry Clinical Biochemistry Pharmaceutical Science Transporter Glutamic acid Hydrazide Biochemistry chemistry.chemical_compound chemistry Yield (chemistry) Drug Discovery Molecular Medicine Homology modeling Isoxazole Molecular Biology Microwave
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 23:5931-5935
ISSN:	0960-894X
Popis:	Microwave accelerated reaction system (MARS) technology provided a good method to obtain selective and open isoxazole ligands that bind to and inhibit the Sx c - antiporter. The MARS provided numerous advantages, including: shorter time, better yield and higher purity of the product. Of the newly synthesized series of isoxazoles the salicyl hydrazide 6 exhibited the highest level of inhibitory activity in the transport assay. A homology model has been developed to summarize the SAR results to date, and provide a working hypothesis for future studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::594888fbf8778bb4d4ab7baf7fd6b179 https://doi.org/10.1016/j.bmcl.2013.08.080 Zobrazit plný text záznamu Full Text from ScienceDirect