| Autor: |
Moncef Zitouna, Ines Chelly, S. Makni, Myriam Kallel Sellami, Mourad Mokni, C. Bouguerra, Amel Ben Osman, A.B. Hmida, Ines Zaraa, A. Sellami |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Journal of the European Academy of Dermatology and Venereology. 25:1160-1167 |
| ISSN: |
0926-9959 |
| Popis: |
Background Pemphigus vegetans (P Veg) is a rare clinical form of pemphigus. Studies on P Veg are rare in the literature and none has so far evaluated the prognostic parameters. Objective In this retrospective study of P Veg, we aimed to analyse epidemiological, clinical, immunopathological and therapeutic data. Study of prognostic factors with accuracy of patient survival was also carried out. Methods This is a retrospective study (1981–2009) including 17 cases of P Veg. Statistical analysis was performed with chi-square and Fisher tests looking for a possible relationship between clinical data and prognostic factors. Follow-up time and disease-free survival time were estimated using Kaplan–Meier methods. Clinical data were evaluated in univariate analysis looking for a significant association with survival. Equality of survival distribution was studied using log rank test. Results The hospital prevalence of P Veg was 0.084‰ with a frequency of 9.1% among pemphigus. The mean age at onset was 47.6 years, with a sex-ratio (F/M) about 4.66. Neumann P Veg was the predominant clinical form (11/17). Clinically, the lesions were multifocal (16/17), prevailed on folds and mucous membranes. Under corticosteroids the mean period for healing was 24 ± 9 days. During the follow-up time, three patients died and 11 patients relapsed. Median of overall relapse-free survival was 13 ± 1.7 months. No significant association between clinical data and prognostic factors was found. Limitations This study was a retrospective chart analysis and the number of patients was small. Conclusion The P Veg seems to be more frequent in Tunisia with high rate of mortality. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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