THE INFLUENCE OF CHRONOBIOLOGICAL RHYTHMS ON TOXICITY OF ISONIAZID AND RIFAMPICIN COMBINATION UNDER EXPERIMENTAL CONDITIONS IN RATS
Autor: | T. A. Guskova, K. I. Usov, A. V. Mashanov, A. A. Gushchina, G. G. Yushkov |
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Rok vydání: | 2017 |
Předmět: |
business.industry
Isoniazid 04 agricultural and veterinary sciences 010501 environmental sciences Pharmacology bacterial infections and mycoses 040401 food science 01 natural sciences 0404 agricultural biotechnology Toxicity polycyclic compounds medicine business Rifampicin 0105 earth and related environmental sciences medicine.drug |
Zdroj: | Toxicological Review. :24-33 |
ISSN: | 0869-7922 |
DOI: | 10.36946/0869-7922-2017-4-24-33 |
Popis: | Results of an experimental toxicological study on anti-tubercular drugs Isoniazid and Rifampicin at their combined administration are reported . It made it possible to establish antagonistic effect of rifampicin to lethal doses of isoniazid and to elicit a decrease in toxicity of the of isoniazid and rifampicin combination when administrated at the evening time.. |
Databáze: | OpenAIRE |
Externí odkaz: |
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