THE INFLUENCE OF CHRONOBIOLOGICAL RHYTHMS ON TOXICITY OF ISONIAZID AND RIFAMPICIN COMBINATION UNDER EXPERIMENTAL CONDITIONS IN RATS

Autor: T. A. Guskova, K. I. Usov, A. V. Mashanov, A. A. Gushchina, G. G. Yushkov
Rok vydání: 2017
Předmět:
Zdroj: Toxicological Review. :24-33
ISSN: 0869-7922
DOI: 10.36946/0869-7922-2017-4-24-33
Popis: Results of an experimental toxicological study on anti-tubercular drugs Isoniazid and Rifampicin at their combined administration are reported . It made it possible to establish antagonistic effect of rifampicin to lethal doses of isoniazid and to elicit a decrease in toxicity of the of isoniazid and rifampicin combination when administrated at the evening time..
Databáze: OpenAIRE
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