Preparation and characterization of pH-sensitive microparticles based on polyelectrolyte complexes for antibiotic delivery
| Autor: | Marcos L. Dias, Lissette Agüero, Dionisio Zaldívar, Luis Peña, Y. Solís, José Ramón |
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| Rok vydání: | 2014 |
| Předmět: |
Aqueous solution
Materials science Polymers and Plastics Radical polymerization General Chemistry Chloride Controlled release Polyelectrolyte Sodium persulfate chemistry.chemical_compound chemistry Polymer chemistry Drug delivery Materials Chemistry medicine Copolymer medicine.drug Nuclear chemistry |
| Zdroj: | Polymer Engineering & Science. 55:981-987 |
| ISSN: | 0032-3888 |
| Popis: | pH-sensitive microparticles formed by combination of a synthetic copolymer and sodium alginate in presence of calcium chloride were prepared in mild conditions for specific water-soluble drug delivery. The copolymers of acryloxyethyl-trimethylammonium chloride and N-vinyl-2-pyrrolidone were synthesized by radical polymerization in aqueous solution at 60°C using sodium persulfate as initiator. Fourier transform infrared spectroscopic characterization confirmed the structure of the copolymers and their compositions were determined by potentiometric method. Scanning Electron Microscopy study revealed that microparticles have a rough morphology with size ranging from 450 to 800 µm as measured by optical microcopy. Cefotaxime as a model drug was encapsulated in the microparticles to evaluate the in vitro release behavior under different pH conditions. At physiological temperature, the amount of drug released increased with increasing pH. The amount of drug release from microparticles after 24 h (84%) was more extensive in simulated intestinal fluid when compared with acidic pH environment (20%). These preliminary results suggest that the new microparticles can be used as good candidate for oral drug controlled release in the treatment to colon diseases. POLYM. ENG. SCI., 55:981–987, 2015. © 2014 Society of Plastics Engineers |
| Databáze: | OpenAIRE |
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