| Autor: |
Neva B. Watson, Ravi K. Patel, Oyebola O. Oyesola, Nathan Laniewski, Jennifer K. Grenier, Jocelyn Wang, Cybelle Tabilas, Kristel J. Yee Mon, Seth P. Peng, Samantha P. Wesnak, Kito Nzingha, Norah L. Smith, Miles P. Davenport, Elia D. Tait Wojno, Kristin M. Scheible, Andrew Grimson, Brian D. Rudd |
| Rok vydání: |
2022 |
| Popis: |
The immune system is stratified into layers of specialized cells with distinct functions. Recently, Lin28b was shown to serve as a master regulator of fetal lymphopoiesis, programming the development of more innate-like lymphocytes in early life. However, it remains unclear whether Lin28b specifies innate functions in more conventional adaptive lymphocytes. In this report, we discovered that Lin28b promotes the development of a more innate-like lineage of CD8+ T cells that is capable of protecting the host against a wide variety of pathogens in the absence of TCR stimulation. Using RNA-seq and ATAC-seq, we found that Lin28b transcriptionally and epigenetically programs CD8+ T cells to be highly responsive to innate cytokines. We also performed scRNAseq and found that the shift from innate-like CD8+ T cells in early life to adaptive CD8+ T cells in adulthood is mediated by changes in the abundance of distinct subsets of cells. Remarkably, the innate CD8+ T cell subset predominates in early life but is also present in adult mice and humans. Collectively, our findings demonstrate that neonatal CD8+ T cells are a distinct lineage of lymphocytes that provide the host with innate defense in early life.One sentence SummaryHigh-dimensional analysis reveals how Lin28b programs neonatal CD8+ T cells for innate defense. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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