Cocrystal Dissociation under Controlled Humidity: A Case Study of Caffeine–Glutaric Acid Cocrystal Polymorphs
| Autor: | Barry John Aldous, Ernest H. H. Chow, Mark D. Eddleston, Joseph F. Krzyzaniak, William Jones, Mihails Arhangelskis, Ranjit Thakuria, Kashyap Kumar Sarmah |
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| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Organic Chemistry Crystal structure Glutaric acid 010402 general chemistry 01 natural sciences Cocrystal Dissociation (chemistry) 0104 chemical sciences chemistry.chemical_compound Crystallography Dicarboxylic acid chemistry Molecule Relative humidity Particle size Physical and Theoretical Chemistry |
| Zdroj: | Organic Process Research & Development. 23:845-851 |
| ISSN: | 1520-586X 1083-6160 |
| DOI: | 10.1021/acs.oprd.8b00422 |
| Popis: | Caffeine–glutaric acid cocrystal polymorphs, Form I and Form II, are presented as a model system to study cocrystal dissociation under controlled humidity. On the basis of relative humidity (RH) data, it was observed that Form I transforms to Form II at high RH and that the rate of the polymorphic phase transformation increases with increasing RH, with the relative stability of the cocrystal following a trend similar to that of the coformer deliquescence point for other caffeine dicarboxylic acid cocrystals. In addition, reduction in particle size, change in crystal morphology with greater number of crystal faces exposed to surrounding atmosphere, and internal arrangement of molecules in the crystal structure are shown to influence cocrystal instability and favor dissociation under increased humidity. |
| Databáze: | OpenAIRE |
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