Baylis-Hillman Reactions of 2-(Trifluoroacetyl)-1,3-azoles

Autor:	Oleg V. Shishkin, Dmitriy M. Volochnyuk, Pavel V. Khodakovskiy, Alexander Shivanyuk, Andrey A. Tolmachev
Rok vydání:	2008
Předmět:	Reaction conditions chemistry.chemical_compound Allylic rearrangement chemistry Nucleophile Organic Chemistry Michael reaction Baylis–Hillman reaction Acrylonitrile Methyl acrylate Medicinal chemistry Catalysis Adduct
Zdroj:	Synthesis. 2008:3245-3252
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-0028-1083150
Popis:	2-(Trifluoroacetyl)-1,3-azoles readily react with methyl acrylate and acrylonitrile under Baylis-Hillman reaction conditions to afford heterocyclic trifluoromethyl-containing allylic alcohols in 36-97% yields. The thus obtained Baylis-Hillman adducts readily undergo Michael addition reactions with various nucleophiles.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::591aa7c4ae4168ce7f35ce2a88b8d021 https://doi.org/10.1055/s-0028-1083150 Zobrazit plný text záznamu