ChemInform Abstract: Facile Access to γ-Aminothiols from 1,3-Thiazines via a Microwave-Assisted Three-Component Reaction

Autor:	Mihaela Gulea, Jean-François Lohier, Rémi Legay, Vincent Reboul, Flavie Peudru
Rok vydání:	2013
Předmět:	chemistry.chemical_classification Hydrolysis Chemistry Component (thermodynamics) Organic chemistry Salt (chemistry) General Medicine Microwave assisted
Zdroj:	ChemInform. 44
ISSN:	0931-7597
DOI:	10.1002/chin.201310028
Popis:	A new efficient and general synthetic methodology to access γ-aminothiols was investigated and developed. 1,3-Thiazines were used as convenient precursors and were prepared by a fast microwave-assisted three-component reaction (3CR) of thioamides, aldehydes, and alkenes. The transformation of thiazines into aminothiols was achieved via a thiazinium salt hydrolysis, in three very facile steps.
Databáze:	OpenAIRE
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