| Autor: |
Eman M. S. Muhammad, Seham A. R Ismail, Ghada S. Osman, Hala S. E Alaa Edin, Mohamed Mostafa Ali Wahman |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
SVU-International Journal of Medical Sciences. 4:112-120 |
| ISSN: |
2636-3402 |
| DOI: |
10.21608/svuijm.2021.112059 |
| Popis: |
Breast cancer is the most frequent malignant tumor in women worldwide. E-Cadherin is a calcium-dependent epithelial cell adhesion molecule that is expressed at adherens junctions. Its loss may result in a poorly differentiated tumorphenotype. Cells with mutated E-cadherin demonstrate increased motility, altered organization of their actin cytoskeletonand associated with metastases, thereby providing evidence for its role as an invasion suppressor.Objectives: Assess the prognostic value of E-cadherin expression in invasive duct carcinoma (IDC) of the breastand to evaluate its correlations with other prognostic parameters.Materials and Methods: Immunohistochemical (IHC) E-Cadherin expression was studied in 60 IDC and the results were correlated with the clinico-pathological parameters.Results: E-cadherin was positive in 46/60 (76.7%) of IDC; 15/60 (25%) showed strong membranous staining. A significant inverse correlation was found between E-cadherin expression and number of lymph node metastasis.Conclusions: Loss of E-cadherin expression is a predictive of invasion and metastasis in IDC. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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