Tufted‐angioma‐like lesion associated with vascular endothelial growth factor and interleukin‐6 in TAFRO syndrome: Is it a common histological feature of multicentric Castleman disease/POEMS syndrome?

Autor:	Kazuhiro Hatta, Kumi Fujita
Rok vydání:	2019
Předmět:	Tufted angioma Pathology medicine.medical_specialty Histology business.industry Castleman disease Dermatology medicine.disease Glomeruloid hemangioma Anasarca Organomegaly Pathology and Forensic Medicine Hemangioma Lesion 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis medicine medicine.symptom business POEMS syndrome
Zdroj:	Journal of Cutaneous Pathology. 46:280-284
ISSN:	1600-0560 0303-6987
DOI:	10.1111/cup.13415
Popis:	The histology of skin lesions of TAFRO (thrombocytopenia, anasarca, reticulin fibrosis/renal failure, and organomegaly) syndrome has rarely been reported. We report herein two cases of TAFRO syndrome with characteristic vascular skin lesions. The lesions resembled a tufted angioma, although those of case 1 partially resembled a glomeruloid hemangioma, which was known as a specific lesion in POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes), a variant of multicentric Castleman disease (MCD). The high titer of serum vascular endothelial growth factor and interleukin-6 could explain common characteristic vascular lesions in both TAFRO syndrome and POEMS syndrome/MCD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::58f22eb87cb353639700e530ac62a1f1 https://doi.org/10.1111/cup.13415 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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