Amantadine hydrochloride inhibition of early and late stages of lymphocytic choriomeningitis virus-cell interactions

Autor:	Raymond M. Welsh, C. M. O'Connell, J.B Kowalski, C. J. Pfau, R.S Trowbridge
Rok vydání:	1971
Předmět:	Infectivity viruses Cell Amantadine Hydrochloride Amantadine Biology Lymphocytic choriomeningitis medicine.disease Virology Virus Microbiology medicine.anatomical_structure Viral replication medicine biology.protein Neutralizing antibody medicine.drug
Zdroj:	Virology. 45:679-686
ISSN:	0042-6822
Popis:	Amantadine hydrochloride inhibits the CA1371, UBC, and WE strains of LCM in both BHK21/13S and L-929 cells. The compound has no direct inactivating effect on virus infectivity nor does it affect the adsorption of virus to cells. By observing the susceptibility of cell-adsorbed virus to neutralizing antibody, amantadine was shown to delay virion penetration. Furthermore, addition of the drug at any time during ongoing viral replication, with all cells scoring as infective centers, inhibits virus synthesis and release.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::58f03070159ef1028a706c4c0b627d8c https://doi.org/10.1016/0042-6822(71)90181-4 Zobrazit plný text záznamu