Stoss therapy is safe for treatment of vitamin D deficiency in pediatric patients undergoing HSCT

Autor: Dana Salzberg, Sandhya Bansal, Lucia Mirea, Jessica Bodea, Holly K. Miller, Roberta H. Adams, Kristen Beebe, Biljana Horn, Alexander Ngwube, Courtney Campbell, Thalachallour Mohanakumar, Paul Castillo
Rok vydání: 2021
Předmět:
Zdroj: Bone Marrow Transplantation. 56:2137-2143
ISSN: 1476-5365
0268-3369
Popis: Vitamin D deficiency remains common among pediatric patients undergoing hematopoietic stem cell transplant (HSCT) despite both aggressive and standard of care strategies. This study examined the safety and efficacy of single high-dose oral vitamin D therapy (Stoss therapy) for treatment of vitamin D deficiency in HSCT recipients. Patients ages 1–21 years presenting for HSCT were randomized to receive either Stoss regimen plus weekly/daily supplementation or standard of care, per US Endocrine Society guidelines. Among the total 48 subjects, 22 (46%) were randomized to Stoss and 26 (54%) to control arms. Baseline 25-hydroxyvitamin D (25-OHD) levels were insufficient/deficient in total of 34 (71%) patients, without difference between treatment groups. The Stoss regimen was well tolerated and no toxicity was observed. At Day +30, mean 25-OHD levels were significantly higher (P = 0.04) with Stoss (42.3 ± 12 μg/l) compared to controls (35.6 ± 14.3 μg/l), and a higher proportion of Stoss patients had adequate vitamin D levels than controls (85% vs 65%). Stoss therapy is a safe and efficacious treatment option for vitamin D deficiency in children undergoing HSCT and may achieve sufficient levels more rapidly than standard of care. This trial was registered at www.clinicaltrials.gov as NCT03176849.
Databáze: OpenAIRE
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