Descriptive analysis of molecular subtypes in Tunisian breast cancer
| Autor: | Michéle V El May, Mansour Ben Abdallah, Ahmed El May, Hamouda Boussen, Rachida Sfar, K. Rahal, Amor Gamoudi, A. Goucha, Bouthaina Dabbabi, Asma Fourati |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Pathology medicine.drug_class business.industry Incidence (epidemiology) Retrospective cohort study General Medicine medicine.disease Gastroenterology Breast cancer medicine.anatomical_structure Oncology Estrogen Hormone receptor Internal medicine medicine Immunohistochemistry Receptor business Lymph node |
| Zdroj: | Asia-Pacific Journal of Clinical Oncology. 10:e69-e74 |
| ISSN: | 1743-7555 |
| DOI: | 10.1111/ajco.12034 |
| Popis: | Aim The objective is to report the correlation between pathology and molecular subtype classifications of breast cancer in Tunisian women. Methods This retrospective study concerned data of 966 breast cancer cases collected from 2007 to 2009 at Salah Azaiz Institute of Tunis. These cases were classified by an immunohistochemistry test for estrogen and progesterone receptors and human epidermal growth factor receptor 2 (HER2) status in the four molecular subtypes, namely luminal A, luminal B, HER2+ and triple negative. The molecular classifications were correlated with the clinicopathological characteristics of the tumors. Results Luminal A (50.7% of cases) was the most common subtype, with triple negative subtype 22.5%, luminal B 13.4% and HER2+ 13.4%. Triple negative and HER2+ subtypes were significantly associated with large tumor size (>5 cm, P |
| Databáze: | OpenAIRE |
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