More efficient iterative uses of tricarbonyliron complexes are possible by diastereoselective formation of η5-cyclohexadienyl complexes

Autor:	Christopher E. Anson, Michael R. Attwood, Donald Smyth, Richard Stephenson, Tony M. Raynham
Rok vydání:	1997
Předmět:	Turn (biochemistry) chemistry.chemical_classification Nucleophile Chemistry Product (mathematics) Organic Chemistry Drug Discovery Organic chemistry Biochemistry Medicinal chemistry Alkyl
Zdroj:	Tetrahedron Letters. 38:505-508
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(96)02360-x
Popis:	Diastereoselective addition of nucleophiles to 1-(RCO)-substituted tricarbony η 4 -cyclohexadiene)iron(0) complexes, and a diastereoselective acid-induced rearrangement to form 1-(branched alkyl)-substituted tricarbonyl( η 5 -cyclohexadienyl)iron(1+) salts, are described. Stereocontrol in the rearrangement has been studied, and HPF 6 , Ac 2 O has been shown to be the most suitable acid to promote diastereoselectivity. The product was reacted with LiCH(SO 2 Ph) 2 , completing one turn of an iterative cycle which formed a chiral centre at each step.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::58eba3c5cd7040c70ceca9f0d85b88df https://doi.org/10.1016/s0040-4039(96)02360-x Zobrazit plný text záznamu Full Text from ScienceDirect