Investigation of the relative infectivity and pathogenicity of different hepatitis C virus genotypes in hemophiliacs
Autor: | JA Ellender, A Chuansumrit, L M Jarvis, Christopher A. Ludlam, E Song, SP Field, Peter Simmonds, FE Preston, L Nemes |
---|---|
Rok vydání: | 1996 |
Předmět: |
Infectivity
education.field_of_study biology business.industry Hepatitis C virus Hepacivirus Immunology Population Cell Biology Hematology Hepatitis C medicine.disease_cause medicine.disease biology.organism_classification Biochemistry Virology Genotype frequency Flaviviridae Genotype Medicine business education |
Zdroj: | Blood. 87:3007-3011 |
ISSN: | 1528-0020 0006-4971 |
Popis: | To assess the relative infectivity and pathogenicity of variants of hepatitis C virus (HCV) genotypes, the distribution of genotypes in hemophilic patients who had been treated with nonvirally inactivated factor concentrates or cryoprecipitates prepared from local blood donors was compared with those found in the respective blood donor populations. Genotype frequencies differed markedly in the four countries investigated (Scotland, Hungary, South Africa, and Thailand) but in each, the HCV genotype distributions in hemophiliacs and blood donors were similar. In addition, HCV genotypes in recipients of commercially manufactured concentrates were similar to those found in the US general population. These findings provide no evidence that HCV genotypes differ significantly from each other in replication rate, transmissibility, or infectivity. |
Databáze: | OpenAIRE |
Externí odkaz: |