Autor: |
Lawrence J. Myers, Vitaly Vodyanoy, Suram T. Pathirana, William C. Neely |
Rok vydání: |
1995 |
Předmět: |
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Zdroj: |
Supramolecular Science. 2:149-154 |
ISSN: |
0968-5677 |
DOI: |
10.1016/0968-5677(96)89669-6 |
Popis: |
The incorporation of valinomycin molecules into cadmium stearate multilayers increased complexation of valinomycin with potassium ions and potassium permeability of the multilayers. Valinomycin-cadmium stearate mixed Langmuir-Blodgett multilayers were exposed to aqueous solutions of KCl, NaCl and KClNaCl mixtures in a concentration range of 0.001–100 mM. The current responses of the multilayers indicated a significant dependence on the K+ concentration but not on the Na+ concentration. A marked preference for K+ over Na+ was observed in mixed ion solutions even when the concentration of Na+ exceeded the concentration of K+ by the factor of 100000. The K+Na+ selectivity was dependent on the concentration of valinomycin in mixed monolayers and was highest at about 9 mol% of valinomycin, at which point the antibiotic molecules were completely surrounded by cadmium stearate molecules. This information may be useful for understanding of fundamental properties of molecular assemblies and antibiotic/cell membrane interactions. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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